532 total citations
22.2 average citations per year

67).
Sakmar, T. P.
Rhodopsin: a Prototypical G Protein-coupled Receptor.
Progr Nucleic Acid Res Mol Biol 59:1–34 (1998).

PMID: 9427838 [PubMed - indexed for MEDLINE]

491 total citations
23.4 average citations per year

60).
Donzella, G. A., Schols, D., Lin, S. W., Esté, J. A., Nagashima, K. A., Maddon, P. J., Allaway, G. P., Sakmar, T. P., Henson, G., De Clercq, E. & Moore, J. P.
AMD3100, a Small Molecule Inhibitor of HIV-1 Entry via the CXCR4 Co-receptor.
Nature Med 4:72–77 (1998).

PMID: 9427609 [PubMed - indexed for MEDLINE]

448 total citations
29.9 average citations per year

13).
Karnik, S. S., Sakmar, T. P., Chen, H. -B. & Khorana, H. G.
Cysteine Residues 110 and 187 are Required for the Formation of Correct Structure in Bovine Rhodopsin.
Proc Natl Acad Sci U S A 85:8459–8463 (1988).

MID: 3186735 [PubMed - indexed for MEDLINE]
PMCID: PMC282477

350 total citations
14.0 average citations per year

46).
Sheikh, S., Zyvaga, T. A., Lichtarge, O., Sakmar, T. P. & Bourne, H. R.
Rhodopsin Activation Blocked by Metal-Ion-Binding Sites Linking Transmembrane Helices C and F.
Nature 383:347–350 (1996).

PMID: 8848049 [PubMed - indexed for MEDLINE]

343 total citations
20.2 average citations per year

15).
Franke, R. R., König, B., Sakmar, T. P., Khorana, H. G. & Hofmann, K. P.
Rhodopsin Mutants That Bind But Fail to Activate Transducin.
Science 250:123–125 (1990).

PMID: 2218504 [PubMed - indexed for MEDLINE]

309 total citations
13.4 average citations per year

79).
Dragic, T., Trkola, A., Thompson, D. A. D., Cormier, E. G., Kajumo, F. A., Maxwell, E., Lin, S. W., Ying, W., Smith, S. O., Sakmar, T. P. & Moore, J. P.
A Binding Pocket for a Small Molecule Inhibitor of HIV-1 Entry Within the Transmembrane Helices of CCR5.
Proc Natl Acad Sci U S A 97:5639–5644 (2000).

PMID: 10779565 [PubMed - indexed for MEDLINE]
PMCID: PMC25881

300 total citations
23.1 average citations per year

17).
Franke, R. R., Sakmar, T. P., Graham, R. M. & Khorana, H. G.
Structure and Function in Rhodopsin. Studies of the Interaction Between the Rhodopsin Cytoplasmic Domain and Transducin.
J Biol Chem 267:14767–14774 (1992).

PMID: 1634520 [PubMed - indexed for MEDLINE]

222 total citations
10.6 average citations per year

11).
Franke, R. R., Sakmar, T. P., Oprian, D. D. & Khorana, H. G.
A Single Amino Acid Substitution in Rhodopsin ( Lysine 248 –-> Leucine) Prevents Activation of Transducin.
J Biol Chem 263:2119–2122 (1988).

PMID: 3123487 [PubMed - indexed for MEDLINE]

208 total citations
8.3 average citations per year

27).
Fahmy, K., Jäger, F., Beck, M., Zyvaga, T. A., Sakmar, T. P. & Siebert, F.
Protonation States of Membrane-Embedded Carboxylic Acid Groups in Rhodopsin and Metarhodopsin II: A Fourier-Transform Infrared Spectroscopy Study of Site-Directed Mutants.
Proc Natl Acad Sci U S A 90:10206–10210 (1993).

PMID: 7901852 [PubMed - indexed for MEDLINE]
PMCID: PMC47743

192 total citations
9.6 average citations per year

92).
Menon, S. T., Han, M. & Sakmar, T. P.
Rhodopsin: Structural Basis of Molecular Physiology.
Physiol Revs 81:1659–1688 (2001). [*Cover Article]

PMID: 11581499 [PubMed - indexed for MEDLINE]

187 total citations
15.8 average citations per year

62).
Dragic, T., Trkola, A., Lin, S. W., Nagashima, K., Kajumo, F., Allaway, G., Wu, L., MacKay, C., Sakmar, T. P., Maddon, P. J. & Moore, J. P.
N-Terminal Substitutions in the CCR5 Co-receptor Impair gp120 Binding and HIV-1 Entry.
J Virol 72:279–284 (1998).

Full Text Available
PMID: 9420225 [PubMed - indexed for MEDLINE]
PMCID: PMC109374

175 total citations
11.7 average citations per year

30).
Arnis, S., Fahmy, K., Hofmann, K. P. & Sakmar, T. P.
A Conserved Carboxylic Acid Group Mediates Light-Dependent Proton Uptake and Signaling by Rhodopsin.
J Biol Chem 269:23879–23881 (1994).

PMID: 7929034 [PubMed - indexed for MEDLINE]

168 total citations
8.8 average citations per year

45).
Lin, S. W. & Sakmar, T. P.
Specific Tryptophan UV-Absorbance Changes Are Probes of the Transition of Rhodopsin to Its Active State.
Biochemistry 35:11149–11159 (1996).

PMID: 8780519 [PubMed - indexed for MEDLINE]

172 total citations
10.1 average citations per year

95).
Sakmar, T. P., Menon, S. T., Marin, E. P. & Awad, E. S.
Rhodopsin: Insights from Recent Structural and Mutagenesis Studies.
Annu Rev Biophys Biomol Struct 31:443–484 (2002).

[Supplementary material available]
PMID: 11988478 [PubMed - indexed for MEDLINE]

147 total citations
13.3 average citations per year

105).
Tsamis, F., Gavrilov, S., Kajumo, F., Seibert, C., Kuhmann, S., Ketas, T., Trkola, A., Palani, A., Clader, J. W., Tagat, J. R., McCombie, S., Baroudy,B., Moore, J. P., Sakmar, T. P. & Dragic, T.
Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry.
J Virol 77:5201–5208 (2003).

PMID: 12692222 [PubMed - indexed for MEDLINE]
PMCID: PMC153966

136 total citations
13.6 average citations per year

31).
Jäger, F., Fahmy, K., Sakmar, T. P. & Siebert, F.
Identification of Glutamic Acid 113 as the Schiff Base Proton Acceptor in the Metarhodopsin II Photointermediate of Rhodopsin.
Biochemistry 33:10878–10882 (1994).

PMID: 7916209 [PubMed - indexed for MEDLINE]

125 total citations
6.6 average citations per year

77).
Ernst, O. E., Meyer, C., Marin, E. P., Fu, W. –Y., Sakmar, T. P. & Hofmann, K. P.
Mutation of the Fourth Cytoplasmic Loop of Rhodopsin Affects Binding of Transducin and Peptides Derived from the Carboxyl-terminal Sequences of Transducin a and g Subunits.
J Biol Chem 275:1937–1943 (2000).

PMID: 10636895 [PubMed - indexed for MEDLINE]

123 total citations
9.5 average citations per year

20).
Chan, T., Lee, M. & Sakmar, T. P.
Introduction of Hydroxyl-Bearing Amino Acids Causes Bathochromic Spectral Shifts in Rhodopsin: Amino Acid Substitutions Responsible for Red-Green Color Pigment Spectral Tuning.
J Biol Chem 267:9478–9480 (1992).

PMID: 1577792 [PubMed - indexed for MEDLINE]

117 total citations
5.6 average citations per year

106).
Yan, E. C., Kazmi, M. A., Ganim, Z., Hou, J. M., Pan, D., Chang, B. S. W., Sakmar, T. P. & Mathies, R. A.
Retinal Counterion Switch in the Photoactivation of the G Protein-Coupled Receptor Rhodopsin.
Proc Natl Acad Sci U S A 100:9262–9267 (2003).

Full Text Available
PMID: 12835420 [PubMed - indexed for MEDLINE]
PMCID: PMC170906

116 total citations
11.6 average citations per year

25).
Fahmy, K. & Sakmar, T. P.
Regulation of the Rhodopsin-Transducin Interaction by a Highly Conserved Carboxylic Acid Group.
Biochemistry 32:7229–7236 (1993).

PMID: 8343512 [PubMed - indexed for MEDLINE]

102 total citations
6.0 average citations per year

76).
Marin, E. P., Gopala Krishna, A., Zyvaga, T. A., Isele, J., Siebert, F. & Sakmar, T. P.
The Amino-terminal Region of the Fourth Cytoplasmic Loop of Rhodopsin Modulates Rhodopsin-transducin Interaction.
J Biol Chem 275:1930–1936 (2000).

PMID: 10636894 [PubMed - indexed for MEDLINE]

98 total citations
9.8 average citations per year

129).
Periole, X., Huber, T., Marrink, S. J. & Sakmar, T. P.
G Protein-coupled Receptors Self-assemble in Dynamics Simulations of Model Bilayers.
J Am Chem Soc 129:10126–10132 (2007).

PMID: 17658882 [PubMed - indexed for MEDLINE]

92 total citations
15.3 average citations per year

125).
Botelho, A. V., Huber, T., Peterson, F. C., Sakmar, T. P. & Brown, M. F.
Curvature and Hydrophobic Forces Drive Oligomerization and Modulate Activity of Rhodopsin in Membranes.
Biophys J 91:4464–4477 (2006).

Full Text Available
PMID: 17012328 [PubMed - indexed for MEDLINE]
PMCID: PMC1779922

87 total citations
13.4 average citations per year