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Sept 14, 2012 | Keynote News

Professor Sakmar to present Keynote lecture at regional Biophysical Society Meeting, Physics and Chemistry of Biological Systems, at Lehigh University?


 
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Sept 7, 2012 | Meeting News

Professor Sakmar welcomes an international panel of scientists to a symposium at the Nobel Forum, Karolinska Institutet, Stockholm, Sweden

"Harnessing Nature's high performance materials for regenerative medicine"


 

 
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May 7, 2012 | ACS Chemical Biology


Amy Grunbeck's paper highlighted as 2nd "Most Read Article" in ACS Chemical Biology in April 2012


 
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April 24, 2012 | Biochemistry

Amy Grunbeck's paper highlighted as "Most Read Rapid Report" in Biochemistry in 2011

 


 
 

aFeb 25, 2012 | 2012 Biophysical Society Meeting

Biophysical Society selects two SakmarLab abstracts for platform presentations. 
SakmarLab members submitted a total of six abstracts. 
Dr. Sakmar will lecture, Amy Grunbeck and Adam Knepp will present platform talks and three other lab members will present posters.

 

 

 


 
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Nov 9, 2011| Obituaries & Tributes


Har Gobind Khorana (1922-2011)

In addition to the attached tributes by Dr. Sakmar, an obituary of Prof. Khorana appears in the Nov 14, 2011 issue of The New York Times, and in a many other print and on-line publications.

[link to .pdf of paper PLOS Biology]
[link to .pdf of paper ACS Chemical Biology]


 
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July 10, 2010 | Obituary

 

Marc Chabre (1936–2010), pioneering quantitative biologist, dies on July 10, 2010


 
Description: :Breaking Bad logo.jpeg

April 18, 2010 | AMC

Respect for Chemistry Highlighted in Hit AMC Series,
Breaking Bad

Walt (Bryan Cranston) explains his motivation to Gus (Giancario Esposito), who surprises him with a state-of-the-art process chemistry lab.

Images and video clip courtesy of:
©2010 AMC

"I simply respect the Chemistry.  The Chemistry must be respected."


 
  Kelly Daggett Paper most downloaded of 2009 ???not sure why this was here....more data needed???
 
 

April 11, 2010 | Nature Online

"Tracking G-protein-coupled receptor activation using genetically encoded infrared probes"

Heptahelical G protein-coupled receptors (GPCRs) in cell membranes act as molecular switches. Precisely how receptors turn on in response to ligand binding is not known. To track the earliest protein conformational changes in the receptor activation pathway, Shixin Ye of the Sakmar Lab and an international team of collaborators engineered rhodopsin, a prototypical GPCR, to contain unique azido probes. The engineered receptors were interrogated by FTIRdifference spectroscopy to show that certain light-induced conformation changes happen much more quickly than had been expected.


 
 

April 11, 2010 | Rockefeller Newswire

"New probe technology illuminates the activation of light-sensing cells."

Through ingenious combinations of roughly 20 amino acids, the basic building blocks of life, genes can build the proteins that comprise everything from the simplest bacteria to the human brain. In new research published today in Nature, scientists unveil a new technique to illuminate the function of those proteins. The method of genetically targeting a non-natural amino acid to specific locations within a protein could theoretically be adapted to place a fluorescent probe at any position in any protein in a mammalian cell.


April 12, 2010 | Physorg.com

New probe technology illuminates the activation of light-sensing cells.

Seeing (infra)red. Scientists designed genetically encoded probes to examine the workings of the visual pigment rhodopsin (pictured above) with infrared spectroscopy. The probes revealed that light causes changes in the protein much faster than previously believed.



 

Dec 18, 2009 | Twentieth Century-Fox Film Corporation

'Signal Transduction' Highlighted in Hit Motion Picture, Avatar

Click the image to the right to view the movie clip

Images and video clip courtesy of:
©2009 Twentieth Century-Fox Film Corporation.



 
 

Nov 2009 | 2010 Biophysical Society Meeting Selects Three SakmarLab Abstracts

Members of the SakmarLab submitted six abstracts to the Biophysical
Society Meeting to be held in San Francisco in February 2010.  Three
of the abstracts were chosen by the selection committee for platform
oral presentations.  The other abstracts will be presented in poster
sessions at the meeting.





 
pdf download

June 15, 2009 | Chemical & Engineering News
Tools For Amyloids: Raman and infrared spectroscopic methods give glimpses of difficult-to- see parts of the amyloid formation process..

[Cover Story]


 
Probing the structural transitions in the rhodopsin activation pathway April 26, 2009 | RU Newswire | Nature Chemical Biology | Physorg.com |
 
"FTIR analysis of GPCR activation using azido probes"
Light causes specific changes in the structure of rhodopsin
New tag could enable more detailed structural studies of mammalian proteins by effectively expanding the genetic code, new research reveals a method that could theoretically be adapted to place a fluorescent probe at any position in any protein in a mammalian cell. The new technology could enable single-molecule fluorescent studies in live cells.

pdf NanoscaleToolImageMarch 6, 2008 | RU Newswire | Science Daily |
Nanoscale tool allows scientists to study membrane proteins one at a time A new device is capable of encasing single membrane proteins from living cells, allowing investigators to individually stimulate key proteins with specific molecules and signals in order to precisely define the biological reactions that result.





 
pdf December 23, 2007 | science news
New method enables scientists to see smells Animals and insects communicate through an invisible world of scents. By exploiting infrared technology, researchers at Rockefeller University just made that world visible. Now, with the ability to see smells, these scientists show that the brains of Drosophila melanogaster larvae not only make use of stereo cues to locate odors but also to navigate toward them.




pdf protein imageJune 14, 2007 | science news
Protein is linked to functional development of brain neurons Rockefeller University investigators say that a molecule that helps transport cargo inside nerve cells may have another, critically important, role related to how developing neurons sprout the projections that relay electrical signals within the brain.









 
pdf March 29, 2006 | science news
Lizard’s ‘third eye’ sheds light on how vision evolved A primitive third eye found in many types of lizards, used to detect changes in light and dark and to regulate the production of certain hormones, may help explain how vision evolved and how signals are transmitted from the eyes to the brain. Now, new experiments show that the molecular mechanisms that underlie this parietal eye’s responses to light are similar to those that transmit responses from rod and cone cells in the eye to the brain.




cover

September 2005 | Popular Mechanics | Canadian Broadcasting Co. | Science Daily |

Recreating a Functional Ancestral Archosaur Visual Pigment.
Mol Biol Evol 19:1483–1489 (2002). [*Rated “EXCEPTIONAL” by the Faculty of 1000]
PMID: 12200476 [PubMed - indexed for MEDLINE]

Scientist claim they've grown a part of a 250-million-year-old archosaurus, a creature so old it's actually an ancestor to the dinosaur. Dr. Belinda Chang is a molecular biologist with Rockefeller University's Thomas Sakmar Laboratory. She led the research, and she's in Manhattan.


 
 

January 24, 2003 | Science News

Nobel laureate, British cancer biology researcher elected ninth RU President


 
 

Sept 3, 2002 | Science News

Researchers recreate 240-million year old protein in test tube


 
 

April 8, 2002 | RU Campus News

Rockefeller University Announces Scholarship Fund in Name of Employee Who
Died at World Trade Center


 
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Feb 22, 2002 | RU News Release

"I Love This Place"

Editor's note: Wednesday, Feb. 12, Acting
President Thomas P. Sakmar met with the
university's graduate students. The following
comments, written by Sakmar, were the basis of
his remarks to the students.


 

September 2000 | HHMI bulletin |

Mentoring the Youngest Researchers,
Howard Hughes Medical Institute Bulletin, 13:16-19 (2000) .

Student interns in Tom Sakmar's lab work and learn beside their mentors, creating a productive and fun experience for both.
A gangly adolescent seems an unlikely member of the HHMI laboratory of Thomas Sakmar, known for its pioneering studies of rhodopsin, the protein that reacts to light in the retina of the eye. Simuni has done research here since July 1998, working as an intern alongside postdocs, graduate students and lab technicians. Situated on The Rockefeller University campus, it's a friendly place, but an intellectual pressure-cooker— surely, no place for a kid.



 
 

Aug 27, 1999 | Science News |

Researchers Propose New Theory to Explain How Visual Pigments are
“Tuned”