WordCloud
 

170).   
Gupta, R., Kapoor, N., Raleigh, D. P. & Sakmar, T. P. 
Nucleobindin 1 Caps Human Islet Amyloid Polypeptide Protofibrils to Prevent Amyloid Fibril Formation.
            J Mol Biol  xxx:xxx–xxx (2012).  PMID: 22542527
RESEARCH PAPER
 

169).   
Grunbeck, A., Huber, T., Abrol, R., Trzaskowski, B., Goddard, W. A. & Sakmar, T. P. 
Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor.
            ACS Chem Biol  xx:xxx–xxx (2012).  PMID: 22542527
RESEARCH PAPER
 

168).   
Sakmar, T. P.  Har Gobind Khorana (1922-2011): 
Pioneering Spirit.
            PLoS Biol  10:e1001273 (2012). 
COMMENTARY

167

167).
Knepp AM, Periole X, Marrink SJ, Sakmar TP, Huber T.
Rhodopsin forms a dimer with cytoplasmic helix 8 contacts in native membranes.
Biochemistry 51:1819-1821. Epub 2012 Feb 27.
PMID: 22352709 [PubMed - in process]
RESEARCH PAPER

166

166).
Sakmar TP.
Har gobind khorana (1922-2011): chemical biology pioneer.
ACS Chem Biol 7:250-251. doi: 10.1021/cb3000293. No abstract available.
PMID: 22339934 [PubMed - in process]
COMMENTARY

165

165).
Ernst OP, Sakmar TP.
Structural biology: Ion channel in the spotlight.
Nature 482:318-319. doi: 10.1038/482318a. No abstract available.
PMID: 22337049 [PubMed - in process]
COMMENTARY

164

164).
Schwartz, T. W. & Sakmar, T. P.
Structural Biology: Snapshot of a Signalling Complex.
Nature 477:540–541 (2011). PMID: 21956322
COMMENTARY

163

163).
Janz, J. M., Ren, Y., Looby, R., Kazmi, M. A., Sachdev, P. A., Grunbeck, A., Haggis, L., Chinnapen, D., Lin, A. Y., Seibert, C., McMurry, T., Carlson, K. E., Muir, T. W., Hunt, S., III, & Sakmar, T. P.
Direct Interaction Between an Allosteric Agonist Pepducin and the Chemokine Receptor CXCR4.
J Am Chem Soc 133:15878–15881 (2011). PMID: 21905700

RESEARCH PAPER
162 162).
Decaillot, F. M., Kazmi, M. A., Lin, Y., Ray-Saha, S., Sakmar, T. P. & Sachdev, P.
CXCR7/CXCR4 Heterodimer Constitutely Recruits beta-Arrestin to Enhance Cell Migration.
J Biol Chem 286:32188–32197 (2011). PMID: 21730065
[*Highlighted in Editor's Choice section of Science Signaling, E. M. Adler, Shifting Signals with CXCR7. Sci. Signal. 4, ec259 (2011)]
RESEACH PAPER
161 161).
Sakmar, T. P.
Receptors: Clicking Class B GPCR Ligands.
Nat Chem Biol 18:500–501 (2011). PMID: 21769095
COMMENTARY
160 160).
Berro, R., Klasse, P. J., Lascano, D., Flegler, A., Nagashima, K. A., Sanders, R. W., Sakmar, T. P., Hope, T. J. & Moore, J. P.
Multiple CCR5 Conformations on the Cell Surface Are Used Differentially by Human Immunodeficiency Viruses Resistant or Sensitive to CCR5 Inhibitors.
J Virol 85:8227–8240 (2011). PMID: 21680525
RESEARCH PAPER
159 159).
Dimond, P., Carlson, K., Bouvier, M., Gerard, C., Xu, L., Covic, L., Agarwal, A., Ernst, O. P., Janz, J. M., Schwartz, T. W., Gardella, T. J., Milligan, G., Kuliopulos, A., Sakmar, T. P. & Hunt, S. W. 3rd.
G Protein-coupled Receptor Modulation with Pepducins: Moving Closer to the Clinic.
Ann N Y Acad Sci 1226:34–49 (2011). PMID: 21615752
CHAPTERS
158 158).
Mukhopadhyay, P., Huber, T. & Sakmar, T. P.
Probing the Activation Mechanism of Heptahelical Receptors: Experimental Validation of Molecular Dynamics Simulations.
in RSC Drug Discovery Series No. 8. G Protein-Coupled Receptors: From Strucdture to Function. (Giraldo, J. & Pin, J.-P., eds.) Royal Society of Chemistry. 19:375–383 (2011).
CHAPTERS
157

157).
Daggett, K.A. & Sakmar, T. P.
Site-Specific in vitro and in vivo Incorporation of Molecular Probes to Study G Protein-Coupled Receptors.
Curr Opin Chem Biol 15:392–398 (2011). PMID: 21571577
REVIEW ARTICLES
156 156).
Huber, T. & Sakmar, T. P.
Escaping the Flatlands: New Approaches to Study Dynamic Assembly and Activation of GPCR Signaling Complexes.
Trends Pharmacol Sci 32:410–419 (2011). PMID: 21497404
[*Cover Article]
REVIEW ARTICLES
155 155).
Grunbeck, A., Huber, T., Sachdev, P. & Sakmar, T. P.
Mapping the Ligand-Binding Site on a G Protein-Coupled Receptor (GPCR) Using Genetically Encoded Photocrosslinkers.
Biochemistry 50:3411–3413 (2011). PMID: 21417335
[*Highlighted on Biochemistry home page. Ranked among top-20 Most Downloaded Articles May 2011 – June 2011, and 9th Most Downloaded Article in Q2 2011 in Biochemistry]
RESEARCH PAPER
154 154).
Menon, I., Huber, T., Sanyal, S., Banerjee, S., Barré, S., Canis, S., Warren, J.D., Hwa, J., Sakmar, T .P. & Menon, A.K.
Opsin Is a Phospholipid Flippase.
Curr Biol 21:149–153 (2011). PMID: 21236677
RESEARCH PAPER
153 153).
Knepp, A.M., Grunbeck, A., Banerjee, S., Sakmar, T. P. & Huber, T.
Direct Measurement of Thermal Stability of Expressed CCR5 and Stabilization by Small Molecule Ligands.
Biochemistry 50:502–511 (2011). PMID: 21155586
RESEARCH PAPER
152 152).
Tchernychev, B., Ren, Y., Sachdev, P., Janz, J.M., Haggis, L., O'Shea, A., McBride, E., Looby, R., Deng, Q., McMurry, T., Kazmi, M.A., Sakmar, T.P., Hunt, S 3rd & Carlson, K.E.
Discovery of a CXCR4 Agonist Pepducin That Mobilizes Bone Marrow Hematopoietic Cells.
Proc Natl Acad Sci U S A 107:22255–22259 (2010). PMID: 21139054, PMCID: PMC3009824
[*Rated "MUST READ" by the Faculty of 1000 Biology]
RESEARCH PAPER
151

151).
Zaitseva, E., Saavedra, M., Banerjee, S., Sakmar, T. P. & Vogel R.
SEIRA Spectroscopy on a Membrane Receptor Monolayer Using Lipoprotein Particles as Carriers.
Biophys J 99:2327–2335 (2010). PMID: 20923668
RESEARCH PAPERS
150

150).
Kapoor, N., Gupta, R., Menon, S.T., Folta-Stogniew, E., Raleigh, D.P. & Sakmar, T. P.
Nucleobindin 1 Is a Calcium Regulated Guanine Nucleotide Dissociation Inhibitor of G{alpha}i1.
J Biol Chem 285:31647–31660 (2010). PMID: 20679342
RESEARCH PAPER

149

149).
Sakmar, T. P.
Examining Receptor Activation: New technologies reveal how G protein-coupled receptors recognize ligands and talk to intracellular partners.
Eur Pharm Rev 3:49–53 (2010).
REVIEW ARTICLES

148 148).
Hou, H.J.M. & Sakmar, T. P.
Methodology of Pulsed Photoacoustics and Its Application to Probe Photosystems and Receptors.
Sensors 10:5642–5667 (2010). PMID: 22219680
REVIEW ARTICLES
147

147).
Ye, S., Zaitseva, E., Caltabiano, G., Schertler, G. F. X., Sakmar, T. P., Deupi, X. & Vogel, R.
Tracking G Protein-coupled Receptor Activation Using Genetically Encoded Infrared Probes.
Nature 464:1386–1389 (2010). PMID: 20383122
[*Rated "RECOMMENDED" by the Faculty of 1000 Biology]
RESEARCH PAPER
146

146).
Miller, J., Agarwal, A., Devi, L. A., Fontanini, K., Hamilton, J. A., Pin, J. P., Shields, D. C., Spek, C. A.,Sakmar, T. P., Kuliopulos, A. & Hunt, S. W., 3rd.
Insider Access: Pepducin Symposium Explores a New Apprach to GPCR Modulation.
Ann N Y Acad Sci 1180:E1–E12 (2009). PMID:19925639
RESEARCH PAPER

145 145).
Ahuja, S., Eilers, M., Hirshfeld, A., Yan, E. C. –Y., Ziliox, M., Sakmar, T. P., Sheves, M. & Smith, S. O.
6-s-cis Conformation and Polar Binding Pocket of the Retinal Chromophore in the Photoactivated State of Rhodopsin.
J Am Chem Soc 131:15160–15169 (2009). PMID: 19795853
RESEARCH PAPER
144 144).
Kapoor, N., Menon, S. T., Chauhan, R., Sachdev, P., & Sakmar, T. P.
Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins.
J Mol Biol 393:882–897 (2009). PMID: 19703466
RESEARCH PAPER
143 143).
Ye, S., Huber, T., Vogel, R. & Sakmar, T. P.
FTIR Analysis of GPCR Activation using Azido Probes.
Nat Chem Biol 5:397–399 (2009). PMID: 19396177
RESEARCH PAPER
142 142).
Ahuja, S., Hornak, V., Yan, E. C. –Y., Syrett, N., Goncalves, J. A., Hirshfeld, A., Ziliox, M., Sakmar, T. P., Sheves, M., Reeves, P. J., Smith, S. O. & Eilers, M.
Helix Movement Is Coupled to Displacement of the Second Extracellular Loop in Rhodopsin Activation.
Nat Struct Mol Biol 16:168–175 (2009). PMID: 19182802
CHAPTERS
141 141).
Sakmar, T. P. & Huber, T.
Rhodopsin.
in Encyclopedia of Neuroscience. (Squire, L. R., ed.) Oxford: Academic Press. 8:365–372 (2009).
CHAPTERS
140

140).
Sakmar, T. P.
Structure and Function of G Protein-Coupled Receptors: Lessons from Recent Crystal Structures.
in Handbook of Cell Signaling, 2nd edition. (Bradshaw, R. A. & Dennis, E. A., eds.) Oxford: Academic Press. pp. 151–156 (2009).
CHAPTERS

139 139).
Seibert, C., Veldkamp, C.T., Peterson, F.C., Chait, B.T., Volkman, B.F. & Sakmar, T.P.
Sequential Tyrosine Sulfation of CXCR4 by Tyrosylprotein Sulfotransferases.
Biochemistry 47:11251–11262 (2008). [*Ranked among top-20 Most Downloaded Articles in Biochemistry Dec. 2008 – Jan. 2009]. PMID: 18834145
RESEARCH PAPER
138 138).
Huber, T., Menon, S. & Sakmar, T. P.
Structural Basis for Ligand Binding and Specificity in Adrenergic Receptors: Implications for GPCR-Targeted Drug Discovery.
Biochemistry 47:11013–11023 (2008). [*Ranked Most Downloaded Article in Biochemistry Oct. – Dec. 2008; Ranked among top-20 Most Downloaded Articles Oct. 2008 – Nov. 2009]. PMID: 18821775
RESEARCH PAPER