Pallavi Sachdev Pallavi Sachdev, Research Associate

Laboratory of Molecular Biology and Biochemistry
Rockefeller Research Building 510

The Rockefeller University, Box 187
1230 York Avenue
New York, NY 10065

Telephone: 212-327-8284
Fax: 212-327-7904

sachdep@rockefeller.edu


pdfCurriculum Vitae

figure1Education:

2002-2007 - Postdoctoral Associate, The Rockefeller University
1996-2002 - Ph.D. in Biochemistry and Molecular Biology, Mount Sinai-New York University School of Medicine,  
1996 - M.P.H. in Epidemiology and Biostatistics, New York Medical College, Graduate School of Health Sciences,  
1993 - B.S. in Biological Sciences, Cornell University







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figure2Research:

Role of chemokine receptors CXCR4 and CXCR7 in tumor growth and metastasis
Allosteric modulation of G protein coupled receptors by receptor dimerization
Role of non-canonical heterotrimeric G protein signaling pathways in cell growth and differentiation












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figure3Awards:

Tri-Institutional Stem Cell Initiative, 2006
Murray Foundation Research Grant, 2005
National Institutes of Health, National Eye Institute Vision Training Grant, 2002-2003










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Published Papers:

10).
Sachdev, P., Tirunagari, L.M., Kappei, D., Unson, C.G. (2009)
Monitoring glucagon and glucagon antagonist-mediated internalization: a useful approach to study glucagon receptor pharmacology.
Adv Exp Med Biol. 2009; 611:325-326

PMID: 19400212 [PubMed - indexed for MEDLINE]

9).
Ye, S., Köhrer, C., Huber, T., Kazmi, M., Sachdev, P., Yan E.C., Aditi Bhagat, RajBhandary, U.L., & Sakmar T.P.
Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.
J Biol Chem2007; 283(3):1525-1533

PMID: 17993461 [PubMed - indexed for MEDLINE]

8).
Sachdev, P., Menon, S., Kastner, D.B., Chuang, J.Z., Yeh, T.Y., Conde, C., Caceres, A., Sung, C.H. & Sakmar, T.P.
G protein betagamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth. 
The EMBO Journal 2007; 26:2621–2632

PMID: 17491591 [PubMed - indexed for MEDLINE]
pdf download 7).
Sachdev, P., Zeng, L. and Wang, L.-H.  
Distinct role of phosphatidylinositol 3-kinase in Vav3-mediated cell transformation, cell motility and cell morphology changes.
J. Biol. Chem. 2002; 277: 17638-17648

PMID: 11884391 [PubMed - indexed for MEDLINE]
pdf download 6).
Nguyen, K.T., Zong, C.S., Uttamsingh, S., Sachdev, P., Bhanot, M., Le, M.T., Chan, J.L., and Wang, L.-H.
The role of phosphatidylinositol 3-kinase, Rho family GTPases, and Stat3 in Ros-induced transformation. 
J. Biol. Chem. 2002; 277: 11107-11115.

PMID: 11799110 [PubMed - indexed for MEDLINE]
pdf download 5).
Sachdev, P., Jiang, Y, Li W., Miki, T., Maruta, H., Nur-E-Kamal, M.S.A., Wang, LH.  (2001).
Differential requirement for Rho family GTPases in an oncogenic IGF-1 receptor-induced cell transformation.
J. Biol. Chem. 2001; 276: 26461-26471

PMID: 11346642 [PubMed - indexed for MEDLINE]
pdf download 4).
Zeng, L., Sachdev, P., Yan, L., Chan, J., Trenkle, T., McClelland, M., Welsh, J., and Wang, LH. (2000).
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.
Mol. Cell Biol. 2000; 20: 9212-9224

PMID: 11094073 [PubMed - indexed for MEDLINE]
MANUSCRIPTS SUBMITTED AND IN PREPARATION
3).
Kapoor, N., Menon S.T., Chauhan, R., Sachdev, P., and Sakmar, T.P.
Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins.
Manuscript submitted Journal of Molecular Biology
2).
Decaillot, F., Kazmi, M., Sakmar, T.P., and Sachdev, P.
CXCR7/CXCR4 heterodimer constitutively recruits b-arrestin to enhance cell migration.
Manuscript in preparation

1).
Banerjee S., Sachdev, P., Grunbeck A., Huber T., and Sakmar T.P.
Efficient microincorporation of human CCR5 into nanoscale discoidal lipid particles.
Manuscript in preparation

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Recent Presentations:


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Posters:
pdf download

5).
Banerjee, S., Grunbeck, A., Huber, T., Sachdev, P., and Sakmar T.P.
Rapid Incorporation of Heterologously Expressed GPCR CCR5 in Nanoscale Apolipoprotein Bound Bilayers (NABBs).
The 53rd Annual Biophysical Society Meeting
February 28 - March 4, 2009. Boston, MA.
pdf download 4).
Sachdev, P., Menon, S., Yeh., T.Y., Conde, C., Caceres, A., Sung, C.H., and Sakmar, T.P.
Role of G protein bg subunit and dynein light chain Tctex-1 in neuronal differentiation
Rockefeller University Postdoctoral Retreat
September 22, 2007. New York, NY.
pdf download 3).
Sachdev, P., Sung, CH and Sakmar, TP.
Role of Gbg and Tctex-1 in neurite outgrowth and neuronal differentiation of primary hippocampal neurons.
The 46th American Society for Cell Biology Annual Meeting
December 9-13, 2006. San Deigo, CA.
pdf download 2).
Sachdev, P., Sung, C.H. and Sakmar, T.P.
Heterotrimeric G Protein bg Subunits Interact with the Cytoplasmic Dynein Light Chain Tctex-1.  The 43rd American Society for Cell Biology Annual Meeting,
December 13-17, 2003. San Francisco, CA.

1).
Sachdev, P., Zeng, L., and Wang, L.H. (2001). 
Distinct role of PI3 kinase in Vav3-mediated cell transformation versus cell morphology changes. 
Invited oral presentation at the 17th Annual meeting on Oncogenes: Cancer Cell Signal Transduction, Frederick, MD.