Thomas Haines Thomas Haines, Visiting Professor

Laboratory of Molecular Biology and Biochemistry
Rockefeller Research Building 510

The Rockefeller University, Box 187
1230 York Avenue
New York, NY 10065

Telephone: 212-327-8284
Fax: 212-721-9557
thaines@prdi.org

pdfCurriculum Vitae

Education:

Institution
City College of CUNY
City College of CUNY 
Rutgers the State University

^




Degree
B. S.
M. S.
Ph. D.


Year
1957
1959
1964

Research:

Biochemistry, Biophysics, Lipids in Membranes and Cell Biology.
Specific biological roles of membrane lipids: cholesterol, cardiolipin, isoprenes, isopranes, chains of fatty acids (including polyunsaturated), chlorosulfolipids, phospholipid headgroups, & membrane protein/lipid interactions.


^

Awards:

Visiting Professor
Who’s Who in America, Who’s Who International (2005-pres.)
Chaired Symposium, “Should a Year of Organic Chemistry be Required for Medical School Admission?”, ASBMB/ACS Joint Meeting, San Francisco, CA, (1995).
Biochemistry and Cell Biology Study Section of NIH Institute for Alcoholism and Alcohol Abuse, 1992-95
Twentieth Anniversary Medal, for establishing the CUNY Medical School, (1993).
Honored Professor Award; CUNY Medical School; (1982, 1983, 1986, 1988, 1989, 1992, 1993, 1995).
Member, Association of Graduate and Medical Schools Biochemistry Chairs, (1986-pres.)
Chair, Biophysics Section, New York Academy of Science (1991-1993).
Chair, Symposium on Membrane Dynamics, The biophysical Society, Phoenix, AZ (1988)
Member, American Society of Biological Chemists, Education Committee, (1986-1991)
Member, Medical Advisory Committee, Sophie Davis School for Biomedical Education, Other members included all of the Deans of New York’s Medical Schools. (1974-78).
125th Anniversary Medal, City College of CUNY, (1972).
Elected to the American Society of Biological Chemists (1970).
Chairman; Symposium on Sulfolipids, American Oil Chemists Society, Houston, TX, (1970).
Co-Chairman; Symposium on Lipids and Monolayers, Amer. Oil Chem. Soc., New York, NY, (1970).
Invited by the USSR Academy of Sciences to chair the first symposium on Lipids ever held at a IUPAC Conference; Riga, USSR (1970).
NATO Senior Fellow: Awarded by the National Science Foundation, Paris, France (1970).
NSF-NIH Joint Travel Award to Tokyo, Japan to attend IUB Conference, (1967) (ASBMB Award).
Honors Fellowship, Rutgers the State University (1963).

 

Books:

 Haines, T. H.
(1972) The Sulfolipids. In series: Progress in the Chemistry of Fats and Oils. Series editor, Ralph Holman. Pergamon Press, NY.

 


^

Published Papers:

41)
Haines, T. H.
(2009) A new look at cardiolipin.
Biochimica et Biophysica Acta—Biomembranes  In Press.

[not indexed on PUBMED]

40)
Bedke, D., Shibuya, G., Pereira, A., Gerwick, W., Haines, T. H., Vanderwal, C.
(2009) Relative stereochemistry determination and synthesis of the major chlorosulfolipid from Ochromonas danica. 
Journal of the American Chemical Society, 131, 7570–7572.

PMID: 19445461 [PubMed - indexed for MEDLINE]

39)
Dante, S., Hauß, T., Dencher, N. A. & Haines, T. H.
 (2005) Localization of coenzyme Q10 in the center of a deuterated lipid bilayer by neutron diffraction.
Biochimica et Biophysica Acta—Bioenergetics 1710, 57-62.

PMID: 16199002 [PubMed - indexed for MEDLINE]

38)
Haines, T. H. & Dencher, N. A.
(2003) Is cardiolipin a proton trap for ATP synthesis?
FEBS Lett. 528, 35-39.  (Includes function of cardiolipin)

[not indexed on PUBMED]

37)
Hauss, T., Dante, S., Dencher, N. A., Haines, T. H.
(2002) Squalene is in the midplane of the lipid bilayer: implications for its function as a proton permeability barrier.
Biochim. Biophys. Acta 1556 149-154.

PMID: 12460672 [PubMed - indexed for MEDLINE]

36)
Mileykovskaya, E., Dowhan, W., Birke, R. L. Zheng, D. & Haines, T. H.
(2001) Cardiolipin binds nonyl acridine orange by aggregating the dye at exposed hydrophobic domains on bilayer surfaces.
FEBS Letters, 507 187-190.

PMID: 11684095 [PubMed - indexed for MEDLINE]

35)
Haines, T. H.
(2001) Do sterols reduce proton and sodium leaks through lipid bilayers?
Progress in Lipid Research, 40, 299-324.   (Includes function of cholesterol)

PMID: 11412894 [PubMed - indexed for MEDLINE]

34)
Paula, S., Volkov, A. G., Van Hoek, A. N., Haines, T. H., Deamer, D. W.
(1996) Permeation of Protons, Potassium ions and small polar molecules through phospholipids bilayers as a function of membrane thickness.
Biophys. J. 70 339-48. (Shows H2O permeability is unaffected by chainlength.)

PMID: 8770210 [PubMed - indexed for MEDLINE]

33)
Mas-Oliva, J., Velasco-Loyden, G. & Haines, T. H.
(1996) Receptor pattern formation as a signal for the capture of lipoproteins.
Biochemical and Biophysical Research Communications 224, 212-218.

PMID: 8694814 [PubMed - indexed for MEDLINE]

32)
Haines, T. H. & Liebovitch, L.
(1995) A molecular mechanism for the transport of water across phospholipid bilayers.  
In “Permeability and Stability of Lipid Bilayers” S. A. Simon and A. Disalvo, eds. CRC Press, Boca Raton FL.  (Includes lateral chain movement vs. H2O permeability of bilayers.)

[not indexed on PUBMED]

31)
Haines, T. H.
(1994) Minireview. Water transport across biological membranes. 
FEBS Letters 346, 115-122.

[not indexed on PUBMED]

30)
Kates, M., Syz, J.Y., Gosser, D. & Haines, T.H.
(1993). pH-dissociation characteristics of cardiolipin and its 2'-deoxy analogue.
Lipids 28, 877-882.

PMID: 8246687 [PubMed - indexed for MEDLINE]

29)
Rutkowski, C. R., Williams, L., Cummins, H. Z. & Haines, T. H.
(1992)  The elasticity of synthetic phospholipid vesicles obtained by photon correlation spectroscopy.  
Biochemistry 31, 5688-96.

PMID: 2043611 [PubMed - indexed for MEDLINE]

28)
Haines, T.H., Li, W., Green, M., & Cummins, H.Z.
(1987). The elasticity of uniform, unilamellar vesicles of acidic.
Biochemistry 26, 5439-5447.

PMID: 3676261 [PubMed - indexed for MEDLINE]


27)
Li, W. & Haines, T.H.
(1986). Uniform preparations of large unilamellar vesicles containing anionic lipids. 
Biochemistry 25, 7477-7483.

PMID: 3542028 [PubMed - indexed for MEDLINE]

26)
Li, W., Aurora, T.S., Haines, T.H., & Cummins, H.Z.
(1986). The elasticity of synthetic phospholipid vesicles and. submitochondrial particles during osmotic swelling.  
Biochemistry 25, 8220-8229.

PMID: 3814581 [PubMed - indexed for MEDLINE]

25)
Aurora, T.S., Li, W., Cummins, H.Z., & Haines, T.H.
(1985). Preparation and characterization of monodisperse unilamellar phospholipid vesicles with selected diameters from 3000 to 6000 Angstroms. 
Biochim. Biophys. Acta 820, 250-258.

PMID: 4052421 [PubMed - indexed for MEDLINE]

24)
Haines, T. H.
(1984) The microbial sulfolipids.  
CRC Handbook of Microbiology. Second Edition. Vol. V.  A. I. Laskin & H. A. Lechevalier, eds. Boca Raton, FL 115-123.

[not indexed on PUBMED]
23)
Haines, T.H.
(1983). Anionic lipid headgroups as a proton-conducting pathway along the surface of membranes: a hypothesis.
Proc. Natl. Acad. Sci. U. S. A. 80, 160-164.

[not indexed on PUBMED]
22)
Haines, T. H.
(1982) A model for transition state dynamics in bilayers.  Implications for the role of lipids in biomembrane transport. 
Biophys. J. 37, 147-9.

[not indexed on PUBMED]
21)
Haines, T.H.
(1979). A proposal on the function of unsaturated fatty acids and ionic lipids: the role of potential compaction in biological membranes.
J. Theor. Biol. 80, 307-323.

[not indexed on PUBMED]
20)
Chen, L.L., Pousada, M., & Haines, T.H.
(1976). The flagellar membrane of Ochromonas danica. Lipid composition.
J. Biol. Chem. 251, 1835-1842.

[not indexed on PUBMED]
19)
Chen, L.L. & Haines, T.H.
(1976). The flagellar membrane of Ochromonas danica. Isolation and electrophoretic analysis of the flagellar membrane, axonemes, and mastigonemes.
J. Biol. Chem. 251, 1828-1834.

[not indexed on PUBMED]
18)
Haines, T. H.
(1974) The halogenated sulfatides. In, “Biochemistry of Lipids.”
In MTP International Review of Science , Biochemistry Vol. IV, T. W. Goodwin. Ed. Pp.271-286.  Butterworths Press, Oxford.

[not indexed on PUBMED]
17)
Haines, T. H.
(1973) Sulfolipids and halosulfolipids.
In, “Lipids and Biomembranes of Eukaryotic Microorganisms.”   Ed., J. A. Erwin, Academic Press, NY.

[not indexed on PUBMED]
16)
Mooney, C. L. & Haines, T. H.
(1973) Chlorination and sulfation reactions in the biosynthesis of chlorosulfolipids in Ochromonas danica, in vivo.
Biochemistry 12,4469-72.

[not indexed on PUBMED]
15)
Haines, T.H.
 (1973). Halogen- and sulfur-containing lipids in protozoa..
Annu. Rev. Microbiol. 27, 403-411.

[not indexed on PUBMED]
14)
Mooney, C. L., E. M. Mahoney, M. Pousada & Haines, T. H.
(1972) Direct incorporation of fatty acids into the halosulfatides of Ochromonas danica.
Biochemistry 11, 4839-44.

[not indexed on PUBMED]
13)
Aaronson, S., U. Behrens, R. Orner & Haines T. H.
(1971) Ultrastructure of intracellular and extracellular vesicles, membranes and myelin figures produced by Ochromonas danica.
J. Ultrastructure Research 35, 418-30.

[not indexed on PUBMED]
12)
Haines, T. H.
(1970) Algae sulfolipids and chlorosulfolipids. 
In, “Properties and Products of Algae.”  J. E. Zajic, ed. New York Plenum Press, pp. 129-142.

[not indexed on PUBMED]
11)
Haines, T. H.
(1970) The reduction of alkyl sulfates to alkane with lithium aluminum hydride.
Lipids 5, 149-151.

[not indexed on PUBMED]
10)
Mayers, G.L., Pousada, M., & Haines, T.H.
(1969). Microbial sulfolipids. 3. The disulfate of (+)-1,14-docosanediol in Ochromonas danica.
Biochemistry 8, 2981-2986.

[not indexed on PUBMED]
9)
Haines, T.H., Pousada, M., Stern, B., and Mayers, G.L.
(1969). Microbial sulpholipids.  IV.  (R)-13-choro-1-(R)-14-docosanediol disulphate and polychlorosulpholipids in Ochromonas danica.
Biochem. J. 113, 565-566.

[not indexed on PUBMED]
8)
Gershengorn, M. C., A. R. H. Smith, G. Goulston, L. J. Goad, T. W. Goodwin & Haines, T. H.
(1968) The sterols of Ochromonas danica and O. malhamensis. 
Biochemistry 7, 1698-1708.

[not indexed on PUBMED]
7)
Haines, T. H.
(1967) A new sulfolipid.  Application to problems of drug transport.  Progr.
In Biochemical Pharmacology, Vol. III, 1848-54

[not indexed on PUBMED]
6)
Mayers, G.L. & Haines, T.H.
(1967). A microbial sulfolipid. II. Structural studies.
Biochemistry 6, 1665-1671.

[not indexed on PUBMED]
5)
Haines, T. H.
(1965) A microbial sulfolipid. I. Isolation and physiological studies.
J. Protozool. 12, 656-659.

[not indexed on PUBMED]
4)
Aaronson, S., B. Bensky, Haines, T. H., J. Gellerman & H. Schlenk.
(1963) Fatty acids of protozoa, especially of phytoflagellates; differences associated with the absence of photosynthetic apparatus in Euglena.  
J. Protozool. 10, 9-12.

[not indexed on PUBMED]
3)
Haines, T. H., S. Aaronson, J. Gellerman & H. Schlenk.  
(1962) Occurrence of arachidonic acid and related acids in the protozoan, Ochromonas danica.  
Nature 194, 1283-4.

[not indexed on PUBMED]
2)
Haines, T. H. & R. Block.
(1962) The sulfur metabolism of algae.  I. Synthesis of metabolically inert chloform-soluble sulfate esters by two Chrysomonads and Chlorella pyrenoidosa. 
J. Protozool. 9, 33-38. 

[not indexed on PUBMED]
1)
Haines, T. H., S. M. Henry & R. Block.
(1960) The sulfur metabolism of insects, V.   The ability of insects to use sulfate in the synthesis of methionine.  
Contrib. Boyce Thompson Inst. 20, 363-5.

[not indexed on PUBMED]

 

^

Recent Presentations:


^

Posters: